Galectin-9 and Attenuation of B-Cell Signalling
Prof. Michael Corrin¹, Dr. Bebhinn Treanor² (content expert)
Undergraduate immunology students
RCSB Protein Data Bank, Adobe Illustrator
This is a molecular biology illustration portraying the role of an adapter protein Galectin-9 in B-Cell immunity. The premise of this research topic was provided by Dr. Bebhinn Treanor at University of Toronto. Molecular structures of proteins involved were referenced from Protein Data Bank (PDB); inter- and intra-cellular details were referenced from histological publications. Illustrator rendering was based on detailed pencil draft.
¹Biomedical Communications, University of Toronto, ²Department of Immunology, University of Toronto
Immunological pathways span multiple magnification scales and are often challenging to communicate to non-specialists or lay audience. With this project, I aimed to create a compelling, understandable visualization of a potential immunological pathway from ongoing research.
2. Background Research
This project was done in collaboration with Dr. Bebhinn Treanor from University of Toronto, who conducted research as portrayed in the piece. Existing publications were investigated alongside information interviews with Dr. Treanor and her lab to consolidate content into a coherent narrative. Protein structures were derived from existing or homologous structural biology data from Protein Data Bank (PDB), visually simplified, and verified by Dr. Treanor.
3. Layout Design
The final deliverable piece for this project was to be printable as a tabloid double-page spread, 11'' x 17''. For establishing layout, factors like magnification scale, narrative flow, perspective, and salience were taken into consideration. A large inset was utilized for a major magnification scale change. A refined tonal pencil draft was created as a visual template for the final rendering.
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